Contact
The ENG4BIO-PBI&PPF center houses the Industrial Biotechnology Platform Service Delivery Laboratories and the UAB Pilot Fermentation Plant, and is a member of the European consortium IBISBA, a research infrastructure in industrial biotechnology. Its expertise focuses on the comprehensive development and exploitation of microbial and enzymatic bioproduction platforms.
Universitat Autònoma de Barcelona (UAB)
Industrial biotechnology; microbial biotechnology; bioprocess engineering; metabolic engineering; synthetic biology; biocatalysis; green chemistry; multi-enzyme systems; circular bioeconomy; carbon capture and use; biomanufacturing; bioprocess scaling
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Technological capabilities
The ENG4BIO-PBI&PPF center offers R&D services in industrial biotechnology with the following capabilities:
- Design of microbial strains: Creation of strains for recombinant production of proteins and metabolites using computational tools, modeling and synthetic biology, such as modular cloning and CRISPR/Cas9. Experience with E. coli and P. pastoris.
- Integrated microbial bioprocesses: Development and intensification of bioprocesses based on microbial cell factories to produce proteins and metabolites, including fermentations in bioreactors operated continuously or discontinuously fed and initial stages of product recovery.
- Biocatalytic processes: Design of reactions with enzymes or multienzyme systems to produce compounds of interest. It includes enzymatic characterization, use of advanced enzyme immobilization techniques, as well as optimization of reactions and reactor operation strategies with soluble or immobilized enzymes.
- Process scaling: Scaling of fermentation processes and initial stages of recovery processes from laboratory to pilot scale to assess their technical and economic feasibility, as well as to produce sufficient quantities of product to evaluate and validate applications.
TOPTechnological fields
Biotechnology
Decarbonization
Green Chemistry, Catalysis and biocatalysis
Bioeconomy
Relevant equipment
- 50 and 250-liter bioreactors, separation equipment (disc/tubular centrifuges, cell disruption and micro/ultrafiltration equipment).
- Bioreactors from 1 to 5 liters, including multiple bioreactors (4x and 2x).
- Enzyme reactors.
ENG4BIO-PBI&PPF location
